Researchers study relationship of oral cancers and periodontal disease
Dental Health • Jul 14, 2010
Today during the 88th General Session & Exhibition of the International Association for Dental Research, in Barcelona, Spain, presenting author J. Meyle, Justus Liebig University, Giessen, Germany, will present an abstract titled “P. gingivalis Infection and Immune Evasion of Oral Carcinomas.”
Meyle and his team are investigating the relationship of oral cancers and periodontal disease. They achieved results by infecting cell carcinoma cells SCC-25 with Porphyromonas gingivalis (P.g.) W83. After 48h the cells were stained with antibodies against human B7-H1, B7-DC and TLR4 and analysed by flow cytometry. RNA was extracted after 24h and gene expression of B7-H1, B7DC, TLR4, IFN-? and IL-10 was quantified by real time PCR and analysed by the ??CT method.
http://www.health.am/ab/more/relationship-of-oral-cancers-and-periodontal-disease/
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